Dubin-Johnson syndrome in brief

Dubin-Johnson syndrome is a very rare syndrome , which is genetic disorder in families , what is dubin johnson syndrome ? , what is the proper management ? , what exactly causes the syndrome ? . 

"Dubin-Johnson Syndrome" or "DJS" is a very rare genetic disorder that causes an individual to have the symptom of jaundice throughout their lifetime. This disorder causes the liver to have the inability to properly break down bilirubin

which is produced by the liver in order to break down the red blood cells in our body that are no longer needed.

This yellowish brown substance is produced by the liver and is normally found in the bile where it breaks down the worn out red blood cells and is eliminated through our feces - stools - which it what gives them their brownish color. When the liver fails to properly metabolize this bilirubin, it causes it to become built up within the blood stream which is what causes the symptom of jaundice.

Causes and Symptoms of Dubin-Johnson Syndrome

Dubin-Johnson Syndrome is very rare and is caused solely by genetics meaning that it is an inherited condition. Dubin-Johnson syndrome is an "autosomal recessive inheritance" meaning that an individual can only acquire Dubin-Johnson syndrome when both parents have the defective gene that causes this condition.

However, while both parents each have one of the mutated genes, they will typically not have any symptoms or signs of this disorder. The primary symptom of this condition is jaundice which is the yellowing of the skin as well as the whites of the eyes. This symptom of jaundice sometimes does not appear until the individual has reached the age of puberty, adolescence, or adulthood.

Typically, patients with Dubin-Johnson syndrome will only have the symptom of jaundice; however, some individuals may experience mild abdominal pain, nausea or vomiting, and weakness.

This symptom of jaundice will continue to be present throughout the individual's lifetime and can worsen due to certain environmental factors that include the use of alcohol, birth control medications, pregnancy, and infections. Complications from Dubin-Johnson syndrome are rare but they can occur and may include jaundice that is severe, and a reduction in liver functioning.

Diagnosis and Treatment

When an individual is experiencing the symptom of persistent jaundice, diagnostic testing may be done for Dubin-Johnson syndrome. These tests may include a blood test that will check the level of bilirubin that is present in the blood, a urine test, and possibly a biopsy of the liver.

Individuals with Dubin-Johnson syndrome typically have a normal life span with no complications from this condition and there is generally no treatment that is needed or prescribed for this condition. In some cases a patient may be prescribed Phenobarbital as this drug has the capability of decreasing the level bilirubin in the system.

While this condition is rare and does cause the symptom of jaundice, it is typically not a serious or life threatening condition; however, there are many other disorders of the liver that can cause this symptom and be a potentially harmful medical condition. Therefore, if you are experiencing any signs of the symptom of jaundice, it is essential that you contact your physician for an evaluation as soon as possible.

Anne Ahira is an established entrepreneur and successful coach in her country of Indonesia. Her success story has been published in many nationwide publications in Indonesia.

Dealing with cases of Jaundice in the cases of patients with the dubin-Johnson syndrome is not the medical issue in the syndrome , as almost all the patients have a normal life span